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Are there any natural or herbal alternatives to senolytic drugs?

Senolytic drugs are a class of medications that target and eliminate senescent cells, which are cells that have entered a state of irreversible growth arrest and are associated with aging and age-related diseases. While senolytic drugs have shown promise in extending healthspan and lifespan in preclinical studies, researchers are also exploring natural or herbal alternatives that may have similar effects.

Natural compounds with senolytic properties

Several natural compounds have been identified for their potential senolytic properties:

• Quercetin: Quercetin is a flavonoid found in various fruits and vegetables, such as apples, onions, and berries. It has been shown to selectively induce apoptosis (cell death) in senescent cells.
• Curcumin: Curcumin is a compound found in turmeric, a spice commonly used in Indian cuisine. It has demonstrated senolytic effects by promoting the clearance of senescent cells.
• Resveratrol: Resveratrol is a polyphenol found in grapes, red wine, and certain berries. It has been shown to have senolytic properties by activating specific pathways involved in senescent cell clearance.
• Fisetin: Fisetin is a flavonoid found in various fruits and vegetables, including strawberries and apples. It has been shown to selectively eliminate senescent cells by inducing apoptosis.

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Herbal extracts with potential senolytic effects

In addition to natural compounds, certain herbal extracts have shown promise in targeting senescent cells:

• Ginkgo biloba: Ginkgo biloba extract has been found to induce apoptosis in senescent cells and improve cognitive function in animal models.
• Green tea extract: Green tea contains polyphenols, such as epigallocatechin gallate (EGCG), which have been shown to have senolytic effects by promoting senescent cell death.
• Chinese skullcap: Chinese skullcap extract has demonstrated senolytic properties by inhibiting the survival of senescent cells.

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It is important to note that while these natural compounds and herbal extracts show promise as potential senolytic alternatives, further research is needed to fully understand their efficacy, safety, and optimal dosage for human use. It is always recommended to consult with a healthcare professional before considering any natural or herbal alternatives to senolytic drugs.

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