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Definition: How does the manipulation of epigenetic marks influence cellular senescence pathways?

Epigenetic marks refer to chemical modifications of DNA and histone proteins that can influence gene expression without altering the underlying DNA sequence. These marks include DNA methylation, histone modifications, and non-coding RNAs. Cellular senescence is a state of irreversible growth arrest that cells enter into in response to various stressors, such as DNA damage or telomere shortening. It is a key process in aging and age-related diseases.

The manipulation of epigenetic marks has been found to play a crucial role in regulating cellular senescence pathways. Changes in DNA methylation patterns, for example, can lead to the activation or repression of specific genes involved in senescence. Histone modifications, such as acetylation or methylation, can also impact the expression of senescence-associated genes.

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Furthermore, non-coding RNAs, such as microRNAs or long non-coding RNAs, have been shown to regulate senescence-related gene expression by interacting with epigenetic machinery. These RNAs can act as either suppressors or promoters of cellular senescence, depending on the specific context.

Overall, the manipulation of epigenetic marks provides a mechanism through which cellular senescence pathways can be modulated. Understanding the intricate interplay between epigenetic modifications and senescence-related gene expression may offer potential therapeutic targets for age-related diseases and interventions to promote healthy aging.

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Keywords: senescence, epigenetic, cellular, modifications, expression, related, manipulation, pathways, histone